Addiction medicine explores the complex biological and psychological roots of substance use disorders, offering hope for more effective treatments and recovery strategies. This field examines how the brain adapts to drugs, the social factors that drive dependency, and the latest clinical approaches to helping individuals regain their lives. By focusing on evidence-based solutions, researchers aim to reduce harm and improve long-term outcomes for patients worldwide.

At Gist.Science, we curate the newest preprints from medRxiv dedicated to this vital area of study. Our team processes every new submission in this category, transforming dense academic findings into accessible plain-language explanations alongside detailed technical summaries. This dual approach ensures that both the general public and specialists can stay informed about the rapidly evolving science behind addiction treatment.

Below are the latest papers in addiction medicine, freshly summarized to help you understand the cutting-edge research shaping the future of recovery.

📄 addiction medicine

Optimising supervised machine learning algorithms predicting cigarette cravings and lapses for a smoking cessation just-in-time adaptive intervention (JITAI)

This study found that while machine learning models can detect smoking lapse risks, their modest overall performance and high inter-individual variability suggest that reducing assessment frequency or simplifying predictors does not consistently improve outcomes, indicating that such algorithms are best used in combination with rules-based approaches rather than as standalone solutions for just-in-time adaptive interventions.

Leppin, C., Brown, J., Garnett, C., Kale, D., Okpako, T., Simons, D., Perski, O.2026-02-27
📄 addiction medicine

Estimating the Smallest Worthwhile Difference (SWD) of Psychotherapy for Alcohol Use Disorder: Protocol for a Cross-Sectional Survey

This protocol outlines a cross-sectional survey using the Prolific platform to estimate the smallest worthwhile difference (SWD) of psychotherapy for alcohol use disorder by assessing trade-offs between benefits and burdens among American respondents, with the goal of informing clinical decision-making and understanding variations across patient subgroups and professional stakeholders.

Sahker, E., Lu, I., Eddie, D., So, R., Luo, Y., Omae, K., Tajika, A., Angelo, J. P., Crisp, T., Coffin, B., Furukawa, T. (…)2026-02-27
📄 addiction medicine

Fighting Addictions, improving Lives through COmprehensive drug rehabilitation with music (FALCO): Protocol for an international randomised controlled trial

The FALCO study is a multinational, assessor-blinded randomized controlled trial involving 600 participants across seven countries that aims to evaluate the long-term efficacy of active music groups and music listening groups compared to treatment as usual in reducing addiction severity and improving recovery outcomes for individuals with substance use disorders.

Geretsegger, M., Meling, H. M. K., Savinova, A., Assmus, J., Dy, C. L., Mydland, T. S., Dybdahl, K., Johansen, B., Koels (…)2026-02-23
📄 addiction medicine

Long-Acting Injectable Buprenorphine Use and Treatment Attribute Priorities Among U.S. Buprenorphine Prescribers: A National Survey

A national survey of U.S. buprenorphine prescribers reveals that long-acting injectable buprenorphine remains underutilized despite high ratings for its attributes, with higher usage observed primarily among clinicians managing larger opioid use disorder caseloads rather than differences in specialty or attitudes toward medication characteristics.

Bormann, N. L., Arndt, S., Oesterle, T. S.2026-02-03